Relevant Research
May 21, 2024
Biomarkers and Cognition Study, Singapore (BIOCIS): Protocol, Study Design, and Preliminary Findings
The focus of medicine is shifting from treatment to preventive care. The expression of biomarkers of dementia and Alzheimer’s disease (AD) appear decades before the onset of observable symptoms, and evidence has emerged supporting pharmacological and non-pharmacological interventions to treat modifiable risk factors of dementia. However, there is limited research on the epidemiology, clinical phenotypes, and underlying pathobiology of cognitive diseases in Asian populations
May 31, 2024
High burden of cerebral white matter lesion in 9 Asian cities
White matter lesions (WML), linked to cerebral small vessel disease, are prevalent in Asia and increase dementia risk. A study of 5701 subjects from 9 Asian cities found WML prevalence highest in stroke/TIA cases (43.3%). Hypertension, hyperlipidemia, and age were key risk factors, affecting cognitive performance.
June 2, 2021
Mild Behavioral Impairment and Cerebrovascular Profiles Are Associated with Early Cognitive Impairment in a Community-Based Southeast Asian Cohort
Mild behavioral impairment (MBI) is one of the earliest observable changes when a person experiences cognitive decline and could be an early manifestation of underlying Alzheimer's disease neuropathology. Limited attention has been given to investigating the clinical applicability of behavioral biomarkers for detection of prodromal dementia.